Gaps can be inserted to represent residues lost or gained by insertions and deletions (indels). These sequences can then be subjected to multiple sequence alignment, a process that involves an attempt to place residues in columns that derive from a common ancestral residue by substitutions. The result of searching databases using the techniques described in Module 4 is the establishment of a list of sequences, either protein or nucleotide, which exhibit significant similarity and are therefore inferred to be homologous. To carry out a multiple sequence alignment using CLUSTALX To select an appropriate multiple sequence alignment program To identify criteria for selecting a multiple sequence alignment program To introduce the different approaches to multiple sequence alignment Editing alignments and producing figures.
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May 2023
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